Indication

Rheumatoid arthritis, Osteoarthritis, Chronic low back pain

Administration

Should be taken with food. Take w/ or immediately after meals.

Adult Dose

Oral Osteoarthritis Adults: 1 tablet twice daily

Child Dose

Oral Osteoarthritis Children over 12 years and older: 1 tablet twice daily

Renal Dose

Renal impairment: CrCl (ml/min) Dosage Recommendation <30 25 mg daily.

Contraindication

Absorption of Diacerein is reduced if taken with aluminium and/or magnesium hydroxide antacid. Diacerein also increases risk of diarrhea if taken with laxatives, antibiotics. Avoid co-administration with fibers and phytic acids. Diacerein has shown hypersensitivity to anthraquinone derivatives.

Mode of Action

Diacerein is an anthraquinone derivative that has been used in osteoarthritis. It is thought to act via inhibition of interleukin-1. Glucosamine stimulates the production of proteoglycans and increases sulfate uptake by articular cartilage.

Precaution

Caution should be practiced when administering Diacerein + Glucosamine Sulphate in those patients who are allergic to Glucosamine and/or Diacerein or to shellfish (e.g., shrimp, crab); who have diabetes, asthma, alcohol dependence or liver disease. Before taking Diacerein + Glucosamine Sulphate complete blood count, liver function and urinalysis should be monitored regularly.

Side Effect

Diarrhea, constipation, epigastric pain, heart burn, nausea, vomiting, headache, skin rashes, drowsiness, intense yellow coloring of urine.

Interaction

Diacerein: Decreased absorption with aluminium and/or magnesium hydroxide antacids. Increased risk of diarrhoea with laxatives, antibiotics. Avoid co-admin with fibres and phytates. Glucosamine: May reduce effect of antidiabetic agents, doxorubicin, etoposide, tenoposide. May enhance anticoagulant activity of warfarin.